Dr. Harry Zall Explains the Difference Between Clinical Depression and the Natural Lows of Life.

Sarah Silverman is known for breaking taboos in her comedy. Her new off-Broadway musical The Bedwetter, adapted from her 2010 memoir of the same name, centers on the most humiliating part of her childhood: wetting the bed every night until she was about 16.

We listen to a 1983 interview with psychologist Timothy Leary, a 1990 interview with spiritual leader Ram Dass and a 2018 interview with How to Change Your Mind author Michael Pollan.

For much of his life, humorist John Moe has dealt with clinical depression that's triggered by stress. Now, faced with the COVID-19 crisis, he says, "my depression wants to flare up."