Terry Gross

Shortly after he was diagnosed with Alzheimer's disease in 2019, architect Brian Ameche, then in his mid-60s, told his wife, novelist Amy Bloom, that he wanted to end life on his own terms, before the disease robbed him of everything.

David Sipress endured years of rejection before finally landing a gig with The New Yorker in '98. "I wasn't about to let all that rejection get in the way," he says. His new memoir is What's So Funny?

Meghan O'Rourke says long COVID and other chronic illnesses put an unwieldy burden on patients, who have to testify to the reality of their own illness. Her new book, The Invisible Kingdom, chronicles her personal struggle to find diagnoses for her own nerve pain, brain fog, extreme fatigue and other symptoms."When you're at the edge of medical knowledge, the lack of evidence is treated as evidence that the problem is you and your mind," O'Rourke says. "I felt, in a sense, kind of locked away in a room like a 19th-century hysteric."